• About
  • 100% Independent reviews of anti-aging products
  • Privacy & Terms
  • Advertise With Us
  • Contact Us

The #1 Blog For Independent Anti-Aging Advice

THE #1 BLOG FOR INDEPENDENT ANTI-AGING ADVICE
  • Anti-Aging
    News
  • Anti-Aging
    Cream Reviews
  • Anti-Aging
    Facial Mask Reviews
  • Anti-Aging
    Eye Cream Reviews
  • Anti-Aging
    Serum Reviews
  • Anti-Aging
    Foods
  • Anti-Aging
    Exercises

Scientists accidentally stop skin aging with Granzyme B

Feb 13, 2015 Best Anti-Aging Anti-Aging Skin Care News 0


Scientists accidentally stop skin aging with Granzyme B

Scientists at the University of British Columbia searching for ways to slow the deterioration of blood vessels may have stumbled on to the key to youthful skin.

The researchers were investigating the effects of a particular enzyme called Granzyme B on blood vessel aging, but they noted something unusual at the end of the study. Mice that had been engineered to lack Granzyme B had perfectly smooth skin, whereas regular control mice were showing signs of age. Could it be that inhibiting this one enzyme is the key to keeping skin youthful and wrinkle-free?

Granzyme B is an enzyme, but more specifically it’s a serine protease. That means it’s capable of breaking down other proteins. It is produced and secreted by immune cells like NK cells and cytotoxic T-cells. It has a variety of functions in the body, but its release by immune cells is also associated with breakdown of the extracellular matrix (ECM). This is the network of proteins and aggregated molecules that fill the space between cells. This may end up being one of the main triggers of visible skin aging.

To test their hypothesis, the team did another experiment with the same type of engineered mice lacking Granzyme B. The mice were exposed to a few minutes of UV light several times a week alongside a control group of mice that had normal Granzyme B expression. You can probably guess what happened. After 20 weeks, the mice without Granzyme B still had pristine, wrinkle-free skin, whereas the control group was starting to show wrinkles.

The researchers believe the skin aging effects of Granzyme B come from its activity in the ECM as mentioned above. It interferes with the structural integrity of collagen, which is the main structural protein in the human body. When the collagen of the ECM is lost, skin wrinkles begin to develop. Sunlight increases the levels of Granzyme B because of its use by immune cells. When your skin cells are virus-infected, damaged by the sun, or develop pre-cancerous mutations, most of them are destroyed by the immune system without you ever knowing. Granzyme B secretion is one of the ways immune cells cause other cells to self-destruct, a process called apoptosis. So it would make sense that levels of this enzyme go up after sunlight exposure.

If we were to use Granzyme B as a target for anti-aging, we’d have to come up with a better way than completely removing it from our DNA. The laboratory mice had no Granzyme B, but it’s an important component of the immune system. Removing all of it would probably result in a plethora of less than desirable consequences. The researchers suggest the use of natural and synthetic inhibitors of Granzyme B (there are a number already known) as a topical treatment after excessive sun exposure. It might be possible to prevent collagen in the skin from being broken down without interfering with the overall job of the immune system.

Beyond the purely cosmetic applications, it’s possible that Granzyme B inhibitors could prevent scarring and damage from photosensitivity diseases of the skin. The team is also still investigating its original analysis of Granzyme B’s role in blood vessel aging, which could lessen the risk of aneurysm.

Sources: http://www.vancouversun.com/scientists+have+accidentally+discovered+secret+wrinkle+free+skin/10658536/story.html#__federated=1 , Geek.com


  • tweet
Related
  • Google made an AR microscope that can help detect cancer!
    Google made an AR microscope that can...

    Apr 21, 2018 0

  • Amino Acids could be the next big thing in Aging!
    Amino Acids could be the next big thing...

    Apr 21, 2018 0

  • Did Avicci die because of excessive drinking and drugs?
    Did Avicci die because of excessive...

    Apr 21, 2018 0

  • Gianluca Vacchi (Dancing Italian) scores hit with “Trump-It”
    Gianluca Vacchi (Dancing Italian)...

    Mar 21, 2018 0

More in this category
  • What are parabens?
    What are parabens?

    Sep 24, 2017 0

  • The DANGERS of using a Charcoal Mask
    The DANGERS of using a Charcoal Mask

    Mar 30, 2017 0

  • BREAKING – Dutch researchers discover “Fountain  of Youth”
    BREAKING – Dutch researchers...

    Mar 25, 2017 1

  • Eye Cream or No Eye Cream?
    Eye Cream or No Eye Cream?

    Dec 01, 2016 1


Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Best Anti-Aging Products

  • MUDMASKY® Facial Detox Purifying Recovery Mask REVIEW
    MUDMASKY® Facial Detox Purifying Recovery Mask REVIEW

    Dec 15, 2015 5

  • Dermalogica Intensive Moisture Balance – REVIEW
    Dermalogica Intensive Moisture Balance – REVIEW

    Nov 04, 2016 1

  • Kiehl’s Creamy Eye Treatment with Avocado REVIEW
    Kiehl’s Creamy Eye Treatment with Avocado REVIEW

    Aug 07, 2015 2

  • Lancôme Visionnaire LR 2412 4% Advanced Skin Corrector REVIEW
    Lancôme Visionnaire LR 2412 4% Advanced Skin Corrector...

    Jul 02, 2014 1

  • Clinique Pore Refining Solutions Instant Perfector REVIEW
    Clinique Pore Refining Solutions Instant Perfector REVIEW

    May 25, 2017 1

Best Anti-Aging Foods

  • Blueberries Skin Benefits
    Blueberries Skin Benefits

    Jul 01, 2014 1

  • Benefits of Carrot for your skin
    Benefits of Carrot for your skin

    Mar 29, 2017 0

  • Tuna Skin Benefits
    Tuna Skin Benefits

    Nov 03, 2014 0

  • Walnuts Skin Benefits
    Walnuts Skin Benefits

    Apr 29, 2015 0

  • Salmon Skin Benefits
    Salmon Skin Benefits

    Sep 21, 2014 0

Best Anti-Aging Exercises

  • Best wrinkle exercises VIDEO
    Best wrinkle exercises VIDEO

    Apr 01, 2015 0

  • Forehead Wrinkle Exercises
    Forehead Wrinkle Exercises

    Sep 16, 2014 2

  • Anti-Aging Exercise, The Owl
    Anti-Aging Exercise, The Owl

    Aug 24, 2016 0

  • How to Stop Frowning – Massage EXERCISE
    How to Stop Frowning – Massage EXERCISE

    Jul 28, 2014 0

  • How to Get Rid of a Double Chin? EXERCISE
    How to Get Rid of a Double Chin? EXERCISE

    Aug 09, 2014 0

Best Anti-Aging Blog

Whether you are looking for the best face mask for your acne, blackheads, dry, oily, or combination skin, or if you are looking for an anti-aging exercise to help you stay young, the latest hollywood anti-aging secrets, the truth about “superfoods” or anything that has to do with aging, you are at the right place!

Big (online) magazines are mostly sponsored. Skincare reviews are not always independent. At bestanti-aging.com our skincare reviews are 100% independent. We have reviewed super popular brands like the glamglow mud mask, but also less well known brands like perricone m.d moisturizer. Or the mudmasky ph-balanced face mask.

Conclusion: BestAnti-Aging.com is your #1 resource for independent anti-aging advice, skin care product reviews, serums, anti-aging tips & more!

Load More...
Follow on Instagram
Copyright 2014-2018 BestAnti-Aging.com | All rights reserved.